Glycerol is a 3-carbon molecule that is classified as an alcohol and is produced naturally by the human body as a result of normal metabolism. Glycerol can also be obtained through the diet as a general recognized as safe (GRAS) food additive. NNB developed HydroPrime™, a breakthrough form of glycerol at the highest concentration on the market, designed to effectively overcome the clumping and stability issues of previous glycerol formulations.
Supports athletic performance and hydration status
Enhances cellular volumization, body composition, and pumps through a non-nitric oxide pathway
May improve endurance, time to fatigue, and recovery
Protective from the negative effects of training in the heat Supports cardiovascular health during exercise
How does HydroPrime® Work?
Glycerol is rapidly absorbed and distributed intra-cellularly, especially in the muscle and vascular tissue. Glycerol increases osmotic drive and total volume of water in the body. When consumed with fluid (e.g. water), fluid retention is enhanced across the body, yielding cellular expansion.
The results of this cellular expansion are greater pumps and hyper-hydration, leading to endurance and performance enhancement. Glycerol has rapidly become one of the best-kept secrets with high-performing athletes and bodybuilders.
HydroPrime by the Numbers
Hydration Support In both Series I (49h) and Series II (32h) experiments, the intake of glycerol results in smaller urine volumes (a 700 ml reduction), demonstrating that glycerol is able to keep a hyperhydrated state for extended periods as long as 32 and 49 hours.
Athletic Performance Support After administration of 1.2 g/kg glycerol in 26 ml/kg solution before exercise, time-to-fatigue is prolonged up to 24% with pre-exercise glycerol. Subjects who consumed glycerol lasted around 94 minutes, compared with 77 minutes for the placebo group. Mean heart rate decreased by 4.4 beats/min with glycerol ingestion.
Thermoregulation Support Compared to pre-exercise hydration with water, exercise following glycerol-induced hyperhydration yielded significantly elevated mean sweat output of 700mL (compared with the water trial mean sweat output of 470mL), representing a 33% increase in the sweat rate.
Glycerol-induced hyperhydration also resulted in lower core temperature (decreased by 0.9°C), demonstrating that pre-exercise glycerol supplementation helps reduce the thermal burden of moderate exercise in heat.
Cardiovascular Support During Exercise Pre-exercise glycerol hyperhydration (1.2g/kg glycerol in a total of 26 mL/kg) decreased urine flow and free water clearance, and continued glycerol ingestion during exercise increased cardiac stroke volume (163.3±27.9 vs 174.4±22.8 mL) and decreased heart rate (128.2±19.0 vs 122.0±14.5 beats/min).
 Koenigsberg P, et al. Life Sciences, 1995, 57(7): 645-653.  Montner P, et al. International Journal of Sports Medicine, 1996, 17(01): 27-33.  Lyons T, et al. Medicine and Science in Sports and Exercise, 1990, 22(4): 477-483.  Montner, P., et al. Journal of Exercise Physiology Online 2.1 (1999).  US FDA. GRAS Notice 640
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